Promising Feature and Challenge of Utilizing Erythropoietin Hormone to Support Emergency Teams’ Activities at High-Altitude Geographical Area

Elva Stiawan(1*), Ratihlia Dhea Widyawati(2),

(1) Department of Chemistry, Faculty of Military Mathematics and Natural Sciences, Republic of Indonesia Defense University, Bogor
(2) Department of Chemistry, Faculty of Military Mathematics and Natural Sciences, Republic of Indonesia Defense University, Bogor
(*) Corresponding Author


After being deployed for any disaster or emergency, both civil and military emergency teams are expected to quickly adapt to a relatively extreme condition of geographical region, such as the possibility of hypoxia in a high-altitude area. In areas with limited amounts of oxygen, an approach to consume a certain dosage of Erythropoietin hormone could be considered to accelerate the red blood cell maturation of the emergency teams’ personnel. Based on its common clinical properties in treating anemia conditions of chronic renal failure patients, this short communication proposed advantages and limitations of the utilization of the Erythropoietin hormone for supporting emergency teams’ performance in terms of hypoxia condition. Because this hormone has been approved by health authorities and widely used for therapeutic purposes, this approach could be wisely considered and further developed with quite a similar purpose in terms of humanity, i.e., to help many victims of the affected area.


Erythropoietin; EPO; Hypoxia; Polypeptides hormone; Red blood maturation

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Shuji Nishi, ‘Effects of Altitude-Related Hypoxia on Aircrews in Aircraft With Unpressurized Cabins’, Mil Med, vol. 176, pp. 79–83, 2011.

D. M. Shaw, G. Cabre, and N. Gant, ‘Hypoxic Hypoxia and Brain Function in Military Aviation: Basic Physiology and Applied Perspectives’, Frontiers in Physiology, vol. 12. Frontiers Media S.A., May 17, 2021. doi: 10.3389/fphys.2021.665821.

D. Wen et al., ‘Erythropoietin Structure-Function Relationships: High Degree of Sequence Homology Among Mammals’, 1993. [Online]. Available:

Jelkmann Wolfgang, ‘Molecular biology of erythropoietin’, Internal Medicine, vol. 43, no. 8, pp. 649–659, 2004.

E. W. Benson, R. Hardy, C. Chaffin, C. A. Robinson, and R. J. Konrad, ‘New Automated Chemiluminescent Assay for Erythropoietin’, 2000.

D. M. Ridley, F. Dawkins, E. Perlin, and N. York, ‘ERYTHROPOIETIN: A REVIEW STRUCTURE OF ERYTHROPOIETIN’, 1994.

A. Hadadi, M. Mortezazadeh, K. Kolahdouzan, and G. Alavian, ‘Does recombinant human erythropoietin administration in critically ill COVID-19 patients have miraculous therapeutic effects?’, J Med Virol, vol. 92, no. 7, pp. 915–918, Jul. 2020, doi: 10.1002/jmv.25839.

EUROPEAN PHARMACOPOEIA 6.0, ‘Erythropoietin concentrated solution’, 2008.

Kemenperin Kementerian Perindustrian, Membangun Kemandirian Industri Farmasi Nasional Buku Analisis Pembangunan Industri-Edisi II 2021. 2021.

A. Marsili et al., ‘Stability of erythropoietin repackaging in polypropylene syringes for clinical use’, Saudi Pharmaceutical Journal, vol. 25, no. 2, pp. 290–293, Feb. 2017, doi: 10.1016/j.jsps.2016.01.003.


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